Structural integrity of MIH-affected teeth after treatment with fluoride varnish or resin infiltration: An 18-Month randomized clinical trial

To evaluate the influence of fluoride varnish (FV) therapies or resin infiltration (RI) to maintain structural integrity Molar Incisor Hypomineralization (MIH) -affected teeth. Fifty-one children aged 6–12 years with at least one incisor and first permanent molar yellow/brown MIH opacities were included. Patients randomly allocated into three groups: FV – Fluoride Varnish (Duraphat); FV+etch (Duraphat) after enamel etching 37% phosphoric acid; RI Resin Infiltration system (Icon). Opacities monitored for 18 months. The primary outcome was loss due post-eruptive breakdown (PEB). Covariables included sex, age, DMFT index, opacity colour, plaque number MIH-affected teeth, surfaces. Fisher’s Exact used test association treatments PEB, Kaplan-Meyer method analysed survival rates Cox-regression determined which covariables would predict failure (α=0.05). From a total 235 PEB rate (6.1%) significantly lower (p<0.05) than (17.9%; OR 3.0, 95%CI 1.07, 8.48) (17.3%; 3.1, 1.13, 8.73). index >3, brown opacities, cusp involvement, age between 6–8 predicted (p<0.05). positively influenced maintenance teeth by decreasing risk over18 months follow-up. Registry Clinical Trials (RBR-8wwk3n). proved be more efficacious intervention therapies.